Few cities in Missouri have a history as closely tied to early Catholic settlement as Perryville. Set in southeastern Missouri, west of the Mississippi River, it is the seat of Perry County amid the rolling terrain of the Ozark Plateau. The Vincentian mission at St. Mary of the Barrens began in 1818 and remains central to local identity; its grounds include the National Shrine of Our Lady of the Miraculous Medal. Perry County also bears traces of French colonial settlement and later German immigration. Browse further webcams across southeastern Missouri to place Perryville in its wider geographic context.
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